There is one primary concern regarding the safety of TG TCR therapy, which is the potential for mispairing between the TG TCR and the endogenous TCR, causing off-target specificity and thereby increasing cytotoxicity. Optimized mechanisms for introducing tumor-specific TCRs into T cells through the transgenic (TG) method have been investigated in humanized mouse models. MO : Humanized mice can be applied to the study of T-cell editing as an evaluation method to optimize the efficacy and safety of TCR/CAR regulation and expand the scope of cancer treatment. Evaluating the efficacy of immunotherapyĪM: Can you tell us more about the use of humanized mice in cancer research?.They benefit a wide range of research fields, including: MO : Humanized mice are important tools for preclinical research that enable researchers to conduct translationally relevant studies. Humanized mice widely serve as models in translational medicine, playing an important role in biological research and drug discovery, including regenerative medicine, transplantation, and immunology.ĪM: What applications can humanized mice particularly benefit? Mouse models have since become irreplaceable for the study of gene function and pathogenesis and have also accelerated the process of drug screening. Therefore, evaluating the drug safety and efficacy through animal models has become the best alternative. Due to medical ethics, we cannot initially test drugs with uncertain effects in the human body. MO: The predominant goal of all biomedical research is to overcome human diseases. Humanized mouse models have become an important animal model for identifying how human genes impact development and disease.ĪM: Why are humanized mice a popular research tool? This type of model is usually used as a powerful in vivo model for preclinical study of human diseases and drug discovery. Marvin Ouyang (MO): A humanized mouse model is a broad term referring to a mouse engrafted with functional human genes, cells, or tissues. Ouyang also explains how humanized mice can be generated and highlights some of Cyagen’s capabilities in this area.Īnna MacDonald (AM): What are humanized mice?ĭr. Marvin Ouyang, Cyagen’s e xecutive vice president and chief scientific officer, to learn more about humanized mice and the applications they can benefit. Technology Networks recently spoke with Dr.
It is now possible to create a range of genetically engineered mouse models, including humanized, knock-in and knock-out models, that can be used to further advance our understanding and treatment of human diseases. Mice are commonly used as models of human disease, helping scientists to understand the workings of complex pathologies and develop safe and efficacious drugs.
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